UWorld Endocrine Practice Test

In hypothyroidism, the thyroid gland produces insufficient amounts of thyroid hormones, leading to an increase in thyroid-stimulating hormone (TSH) levels as the pituitary gland attempts to compensate. Elevated TSH levels are indicative of an underactive thyroid and are associated with a range of clinical symptoms that align with the body's reduced metabolic rate.

Bradycardia, a slower than normal heart rate, is a common manifestation in individuals with hypothyroidism due to decreased thyroid hormone levels, which play a crucial role in regulating heart function and metabolism. Cold intolerance occurs as the body's metabolic processes slow down, diminishing the ability to generate heat and respond effectively to cold environments.

Other symptoms commonly observed in hypothyroidism include fatigue, weight gain, dry skin, hair loss, and cognitive changes. The choice reflecting bradycardia and cold intolerance correctly represents these physiological changes occurring due to elevated TSH levels in the context of hypothyroidism.