Name a common autoimmune disorder related to endocrine dysfunction.

Study for the UWorld Endocrine Test. Dive into flashcards and multiple choice items with explanations and hints. Prepare yourself thoroughly!

Graves’ disease is a common autoimmune disorder that specifically affects the endocrine system by causing hyperthyroidism. In Graves' disease, the body's immune system produces antibodies that stimulate the thyroid gland to secrete excessive amounts of thyroid hormones (such as thyroxine), leading to an overactive metabolism. This condition is characterized by symptoms such as weight loss, heat intolerance, palpitations, and often bulging eyes (exophthalmos).

In contrast, while Type 1 diabetes mellitus is also an autoimmune disorder affecting insulin production in the pancreas, it is primarily a metabolic disorder rather than one that directly impacts the endocrine system like Graves' disease does. Cushing's syndrome is related to excess cortisol production, often due to tumors or adrenal hyperplasia, and is not classified as an autoimmune disorder. Pheochromocytoma is a tumor of the adrenal gland that secretes catecholamines and does not involve an autoimmune mechanism. Hence, Graves' disease stands out as a prevalent autoimmune disorder with a direct impact on endocrine function.

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