What are the symptoms of acromegaly?

Acromegaly is a hormonal disorder that results from excess growth hormone, usually caused by a benign tumor of the pituitary gland. The condition typically manifests after the growth plates have closed, leading to characteristic changes in physical appearance.

One of the hallmark symptoms of acromegaly is the enlargement of hands and feet. Individuals may notice that their rings no longer fit or that they need larger shoes, due to increased bone and soft tissue growth. This enlargement occurs progressively and is a direct result of the elevated levels of growth hormone leading to increased production of insulin-like growth factor 1 (IGF-1), which stimulates growth in bones and tissues.

The other symptoms or conditions listed in the question, while they may be present in some patients with acromegaly, do not specifically define the disorder in the same way. Weight loss and fatigue are not typical features; in fact, patients may experience weight gain due to changes in metabolism and increased appetite. Decreased bone density is not commonly associated with acromegaly; in many cases, patients may actually experience increased bone density due to the effects of growth hormone. High blood pressure can occur as a complication due to the effects of excess growth hormone on the cardiovascular system, but it is not