What role do Leydig cells serve in the male reproductive system?

Study for the UWorld Endocrine Test. Dive into flashcards and multiple choice items with explanations and hints. Prepare yourself thoroughly!

Leydig cells, also known as interstitial cells, play a crucial role in the male reproductive system by producing testosterone. Located in the testes, Leydig cells are stimulated by luteinizing hormone (LH) from the anterior pituitary gland, which prompts them to synthesize and secrete testosterone.

Testosterone is essential for several functions in the male body, including the development of male secondary sexual characteristics (such as facial hair and a deeper voice), the maintenance of libido, and playing a vital role in spermatogenesis indirectly by supporting the function of Sertoli cells, which are responsible for nurturing the developing sperm cells.

While there are other components and cells involved in the male reproductive system, such as those responsible for sperm production or the regulation of fluids, the primary and defining function of Leydig cells is the production of testosterone. This hormonal activity is what primarily distinguishes their role and importance in male reproductive physiology.

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