What serious condition can occur as a complication of untreated hypothyroidism?

Study for the UWorld Endocrine Test. Dive into flashcards and multiple choice items with explanations and hints. Prepare yourself thoroughly!

Myxedema coma is a life-threatening condition that can occur as a complication of untreated hypothyroidism. It represents a severe form of hypothyroidism where the body's metabolism dramatically slows down due to extremely low levels of thyroid hormones. Symptoms can include confusion, hypothermia, bradycardia, and often a decreased level of consciousness. This condition can be precipitated by factors such as infection, trauma, or exposure to cold, particularly in patients with a history of long-standing untreated hypothyroidism.

During myxedema coma, patients may exhibit a range of symptoms, including generalized edema (myxedema), respiratory failure, and cardiovascular collapse. Immediate medical intervention is crucial, involving the administration of thyroid hormone replacement and supportive care in a hospital setting.

In contrast, the other conditions mentioned are either unrelated to untreated hypothyroidism or represent different thyroid dysfunctions. For example, hyperthyroid crisis and thyroid storm refer to severe cases of hyperthyroidism, characterized by excessive thyroid hormone levels leading to symptoms like high fever, tachycardia, and confusion. Cretinism is a condition resulting from congenital hypothyroidism, occurring due to a lack of thyroid hormone during infancy and childhood, leading to developmental issues rather than being an acute complication

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