Which endocrine condition is associated with cafe-au-lait spots?

McCune-Albright syndrome is associated with café-au-lait spots, which are flat, pigmented skin lesions that can vary in size and shape. This syndrome is a genetic disorder caused by a mutation in the GNAS gene, leading to a triad of symptoms: bone dysplasia, precocious puberty, and endocrine abnormalities. The café-au-lait spots in McCune-Albright syndrome are typically larger than those seen in neurofibromatosis and have a characteristic jagged edge.

The presence of café-au-lait spots serves as a crucial clinical marker for diagnosing McCune-Albright syndrome, especially when accompanied by other symptoms of the condition. In contrast, the other endocrine conditions listed, such as Turner syndrome, Cushing's disease, and acromegaly, do not feature café-au-lait spots as a hallmark sign or symptom. Understanding this association helps in recognizing and diagnosing McCune-Albright syndrome effectively.