Which hormone is crucial for sodium retention and water balance in the body?

Study for the UWorld Endocrine Test. Dive into flashcards and multiple choice items with explanations and hints. Prepare yourself thoroughly!

Aldosterone plays a critical role in sodium retention and maintaining water balance within the body. It is a mineralocorticoid hormone produced by the adrenal cortex. Its primary function is to regulate sodium and potassium balance by increasing the reabsorption of sodium in the kidneys, particularly in the distal tubules and collecting ducts.

When aldosterone is secreted, it promotes the insertion of sodium channels and sodium-potassium pumps in the renal tubule cells, which enhances the reabsorption of sodium back into the bloodstream. This process not only helps to maintain electrolyte balance but also increases water retention because water follows sodium osmotically. Consequently, increased sodium retention leads to an increase in blood volume and blood pressure.

Therefore, aldosterone is essential for sodium retention and water balance. The other hormones mentioned—corticosteroids, insulin, and progesterone—have different primary functions, such as regulating stress response, glucose metabolism, and reproductive processes, respectively, but they do not have the same direct impact on sodium and water balance as aldosterone does.

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